![]() She said a simple blood test can diagnose primary biliary cholangitis, and early diagnosis is important. Schranz said symptoms such as fatigue, muscle aches and pains and joint pain are common, and it isn’t necessarily a disease. What symptoms accompany primary biliary cholangitis, and what are the current treatments addressing this liver disease? It’s got an autoimmune component, but there seems to be an event that leads to triggering it and then you get the buildup of the bile acids and the toxicity in the liver,” Schranz said. So there most likely is a genetic predisposition. “And there is some recent epidemiology that the prevalence seems to be increasing. Schranz said around two or three people per 100,000 may have the disease. “It’s a chronic progressive liver disease that many women and men who have this condition may not be diagnosed with until they’ve had it for quite a bit of time because there is a period of time where it’s asymptomatic. And that can lead to complications, and ultimately, the need for a liver transplant, or death. If untreated, this can lead to cirrhosis of the liver due to the toxins. Schranz said this can lead to inflammation of the liver, which then causes many other symptoms, including fibrosis, or scarring. This is where the flow of bile from the liver to the duodenum is impaired. It involves inflammation and storage of toxins and bile acids in the liver that leads to cholestasis. Primary biliary cholangitis is a genetic, chronic, progressive, autoimmune liver disease that affects more women than men. ![]() Jennifer Schranz is senior vice president and global head of rare diseases in the R&D division at Ipsen, and she discusses a breakthrough treatment for primary biliary cholangitis and cholestatic liver disease. On the podcast this week, we are looking at recent advances in treating certain liver diseases.
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